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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically described by their focus on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Pragmatic is a software development company that offers a broad range of casino games on online gambling platforms. Pragmatic's iGaming solutions are used by the leading operators and casinos with a physical location. The company offers front-end design tools, analysis, marketing, promotions, payment systems, security, customer service, and bug reporting. In addition, the company provides its players a safe and secure environment with high-quality graphics as well as gaming.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from various geographical areas. This type of heterogeneity which is essential for a pragmatic trial to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however could cause issues with the design of the trial.

Pragmatic Play is also a major player in the live casino market, offering a wide selection of classic table games such as Blackjack and Roulette in a variety of versions. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling as well a full selection of virtual betting options. The company also hosts a variety of games that make online gambling more enjoyable and engaging. Some of these shows feature live hosts, whereas others are hosted by celebrities from the industry.

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The majority of Pragmatic Play slot games feature traditional themes as well as modern graphics, making them popular with both novices and veteran players. Many of them have progressive jackpots as well as numerous paylines and bonus rounds. They are not volatile, which means you will have a lengthy gaming experience.

Pragmatic Play offers a large selection of games that you can play for free before you decide whether or not to purchase them. The games for free are designed to play on all kinds of devices from tablets to desktops and smartphones. They are simple to navigate and you can play them any time you have an internet connection. Some Pragmatic Play websites even let you test your luck moving around by using a practice mode. This will allow you to get familiar with the game's rules and features before playing with real money.

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Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. The software is available on mobile devices and in multiple languages. Despite its infancy it has already established itself as a leading casino gaming platform. Wolves is one of its latest releases, a 5-reel slot machine with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. Usually, they are ordered by policymakers and practitioners to help guide their decisions. They are also a good method of determining the causality between the intervention and its effects. They should, however, not be used to replace explanation studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a practical trial that include recruitment, design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority of these trials were conducted in primary care settings.